Unfortunately the lift capacity to get to the Elizabeth line at Paddington is inadequately sized to be able to cope with the full number of people with large luggage items. It also requires the use of two lifts - one to get to the ticket hall level and another after the barriers to get to the platform.
I have seen some loose control of their large suitcase on an up escalator at Paddington, fortunately it was near the bottom and people about get on managed to get out of the way.