In the case of Temple Meads of course, the Luftwaffe had a lot to do with it originally. Oh, and the planners who moved in shortly afterwards!
Not sure the Luftwaffe had very much to do with it at all, really.
Temple Meads is a bit of an awkward site, made even more isolated by the routing of the erstwhile Inner Circuit Road along Temple Way and Redcliff Way, and the dual carriageway through Temple Gate. Before that, bustling Victoria St led straight to it - and of course there was a tram terminal right outside.
A bit like Kings Cross of old, Temple Meads has had what to most is a ‘dead zone’ behind it made up of large industrial sites.
What is new is the re-zoning of this area to housing and education. This probably reflects the way the importance of freight has given way to a more passenger-oriented railway.